徐菲    助理教授、研究員
所在學院生命科學與技術學院
iHuman研究所
研究方向結構生物學
聯系方式xufei@@shanghaitech.edu.cn


 
 個人簡介 
2006年獲得中國科技大學生命科學專業學士學位;2011年獲得美國Scripps研究所生物學專業博士學位湖南幸运赛车开奖直播;2011-2012年上海銳意生物技術有限公司董事(銳意公司創始人之一)。2013年9月加入上??萍即髮WiHuman研究所任Research Associate Professor湖南幸运赛车开奖直播,PI。2014年8月兼上??萍即髮W生命科學與技術學院助理教授、研究員。
 主要研究內容 
主要研究內容:1. 探索研究機體發育及癌癥發生信號通路中相關的GPCR蛋白湖南幸运赛车开奖直播;2. 使用膜蛋白晶體學、冷凍電鏡、細胞生物學等結合的手段研究蛋白的結構、配體湖南幸运赛车开奖直播、及信號通路。
 代表性論文 

1. Zhang X, Zhao F, Wu Y, Yang J,Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR,Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W, Tao H,Xu F. Crystal structure of a multi-domain human smoothenedreceptor in complex with a super stabilizing ligand” Nature Communications, 8:15383, (2017)


2. Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, ShenY, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S,Stevens RC, Hu LA, Zhong W, Zhang M, Xu F. StructuralBasis for Apelin Control of the Human Apelin Receptor” Structure, doi:10.1016/j.str.2017.04.008, (2017)


3. Zhang X, Stevens RC, Xu F. The importance of ligands for Gprotein-coupled receptor stability TrendsBiochem Sci. 40(2):79-87, (2015)


4.Liu W, Chun E, Thompson A.A, Chubukov P, Xu F, Katritch V, Han G-W, Roth C.B,Heitman L.H, Ijzerman A.P, Cherezov V, Stevens R.C. “Structural basis forallosteric regulation of GPCRs by sodium ions” Science, 337(6091): 232-236,(2012)

5. Chun E, Thompson A.A, Liu W, Roth C.B, Griffith M.T., Katritch V, Kunken J,Xu F, Cherezov V, Hanson M.A, Stevens R.C. “Fusion Partner Toolchest for theStabilization and Crystallization of G Protein-Coupled Receptors” Structure,20(6): 967-976, (2012)

6. Tosh D.K, Phan K, Gao Z-G, Gakh A.A, Xu F, Deflorian F, Abagyan R, StevensR.C, Jacobson K.A, Katritch V. “Optimization of Adenosine 5’ -CarboxamideDerivatives as Adenosine Receptor Agonists Using Structure-Based Ligand Designand Fragment-Based Searching” J Med Chem, 55(9): 4297-4308, (2012)

7. Deflorian F, Kumar TS, Phan K, Gao Z-G, Xu F, Wu H, Katritch V, Stevens R.C,Jacobson K.A. “Evaluation of Molecular Modeling of Agonist Binding in Light ofthe Crystallographic Structure of an Agonist-Bound A(2A) Adenosine Receptor” JMed Chem, 55(1): 538-552, (2012)

8. Xu F, Stevens R.C. “Trapping small caffeine in a large GPCR pocket”Structure, 19(9): 1204-1207, (2011) Invited Review.

9. Xu F, Wu H, Katritch V, Han G-W, Jacobson K.A, Gao Z-G, Cherezov V, StevensR.C. “Structure of an agonist-bound human A2A adenosine receptor” Science, 332:322-327, (2011)

10. Xu F, Liu W, Hanson M, Stevens R.C, Cherezov V. “Development of anAutomated High Throughput LCP-FRAP Assay to Guide Membrane ProteinCrystallization in Lipid Mesophases” Crystal Growth & Design, 11(4):1193-1201, (2011)

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