王皞鵬    助理教授、研究員
所在學院生命科學與技術學院
研究方向T細胞活性的調節,共刺激/抑制信號通路,腫瘤免疫
聯系方式wanghp@@shanghaitech.edu.cn


 
 個人簡介 
2003年本科畢業于南京大學理科教學強化部;2009年在美國田納西大學健康醫學中心獲博士學位;2009年至2015年在加州大學舊金山分校醫學院進行博士后研究;2015年7月加入上??萍即髮W生命科學與技術學院任助理教授、研究員。 
 主要研究內容 
最近,以免疫細胞為靶標的腫瘤免疫療法取得了重大的突破。免疫學家利用大分子藥物來增強病人自身T細胞的抗癌能力,成功地治愈了癌癥病人。我們的科研工作聚焦于T細胞活化的調節機制,我們結合蛋白質組學,CRISPR篩選以及小鼠遺傳學等方法探索T細胞受體以及共刺激分子CD28 受體家族的下游信號通路。我們的研究將幫助尋找腫瘤免疫的新靶點。
 代表性論文 

1.Tian R*, Wang H*, Pasculescu A, Shi Y, Gish G, Hunter T, Gingras A, Pawson T, Weiss A. Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T cell co-stimulatory receptor PNAS 2015 12; 1594-1603 (*equal contribution)

2.Punwani D*Wang H*, Chan AY, Cowan MJ, Mallott J, Sunderam U, Mollenauer M, Srinivasan R, Brenner SE, Mulder A, Claas FH, Weiss A, Puck JM. Combined Immunodeficiency due to MALT1 Mutations, Treated by Hematopoietic Cell Transplantation.  J Clin. Immunol. 2015 35 135-146(* equal contribution)

3.Wang H*, Flach H*, Onizawa M, Wei L, McManus MT, Weiss A. Negative regulation of Hif1α expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210. Nature Immunology 2014 15; 393–401 (* equal contribution)

4.Zhuang M, Guan S, Wang H, Burlingame AL, Wells JA.Substrates of IAP Ubiquitin Ligases Identified with a Designed Orthogonal E3 Ligase, the NEDDylator. Molecular Cell. 2013 49(2):273-82.

5.Wang H,Kadlecek T, Au-Yeung B, Sj?lin Goodfellow H, Hsu LY, Freedman T, Weiss A.ZAP-70: an essential kinase in T cell signaling. Cold Spring Harb Perspect Biol2010 1;2(5).

6.Wang H, Holst J, Woo S, Guy CS, Bettni M, Wang Y, Aaron S, Naramura M, Mingueneau M, Dragone L, Hayes S, Malissen B, Band H, Vignali DA. Tonic Ubiquitylation controls T cell receptor:CD3 complex expression during T cell development. EMBO J. 2010 7;29(7):1285-98.

7.Wang H, Matsuzawa A, Brown SA, Zhou J, Guy CS, Tseng PH, Forbes K, Nicholsonll TP, Sheppardll PW, Haecker H, Karin M, Vignali DA. Analysis of non-degradative protein ubiquitylation with a monoclonal antibody specific for K63-linked polyubiqutin. PNAS 2008 105(51):20197-202.

8.Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H, Vignali DA, Bergsagel PL, Karin M. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nature Immunology 2008 9(12):1364-70.

9.Holst J, Wang H, Eder KD, Workman CJ, Boyd KL, Baquet Z, Singh H, Forbes K, Chruscinski A, Smeyne R, van Oers NS, Utz PJ, Vignali DA. Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nature Immunology2008 9(6):658-66.

10.Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DA, Gallagher E, Karin M. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.Science 2008 321(5889):663-8

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